바이오의약품 용어, 정의 및 범위, 지칭용어(Terminology), 정의(Definition), 범위(Scope)
지칭 용어
(Terminology) |
- биологические лекарственные препараты (Biological medicinal products)
- БИОМЕДИЦИНСКИЕ КЛЕТОЧНЫЕ ПРОДУКТЫ (Biomedical cellular products)
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정의
(Definition) |
- 의약품의 주요 활성물질을 생물체에서 분리 또는 제조한 의약품으로 그 품질과 특성을 판정하는데 물리화학적 및 생물학적 방식의 조합이 필요한 의약품
- 면역제제(иммунобиологические лекарственные препараты, immunobiological durgs) 알레르기 물질에 대한 면역반응의 특정 변화나 면역을 진단하기 위한 의약품
- 생명공학의약품(биотехнологические лекарственные препараты, biotech drugs, 생명공학기술(DNA재조합기술, 진핵생물과 원핵생물에서 변형된 포유동물 세포를 포함해 생리활성 단백질을 인코딩하는 유전자 발현 조절기술 등)을 이용하여 제조한 의약품
- 유전자치료제(генотерапевтические лекарственные препараты, gene therapy drugs, 원료의약품이 재조합 핵산이거나, 유전자 서열을 조절, 수복, 치환, 삽입 또는 삭제할 수 있는 재조합 핵산을 포함하고 있는 의약품)
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범위
(Scope) |
- (Biological medicinal products)
- 면역제제: 백신, 톡소이드, 독소, 혈청, 면역글로불린, 알레르겐 등
- 전혈을 제외한 혈액제제(кровь, blood products)
- 생명공학의약품 : 단클론항체법 및 하이브리도마(hybridoma)법을 이용해 제조되는 의약품
- 유전자치료제
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인허가 제도
바이오의약품 관련 주요 법률(법령)
바이오의약품 관련 주요 규정(부령)
- Federal Decision N 686 On approval of Regulations "Licensing of Drugs"
- Federal Decision N 650 In connection with the adoption of the federal law "On Handling Drugs"
임상시험 허가 절차
임상시험승인 심사 기관
- 보건부는 임상시험 수행기관 인증, 전임상·임상시험의 관리 및 승인, 임상시험약 수입허가 발급 등의 역할을 수행함으로서, 러시아 내 임상시험 관련 최고 권위를 가지고 있음
- 보건부의 승인 뿐 아니라, 임상시험 의뢰자와 참여 수행기관 간 동의가 필요함
- 해당 기관 소속 윤리위원회의 우호적인 평가 의견 필요
- 임상시험 승인 심사는 전문심사 및 윤리심사 평가 의견을 종합하여 보건부에서 최종 승인을 결정함
- 전문심사는 FSI SCMER의 소관 업무로, 심사 의견을 보건부에 전달함
- 윤리심사는 보건부 소속 윤리위원회 소관 업무로, 심사 의견을 보건부에 전달함
임상시험계획 승인 신청 절차(Investigational New Drug, IND)
- 임상시험 계획 수립 시 임상시험 수행기관은 러시아 보건부(MoH) 인증을 받은 기관이어야 하며, 임상시험 연구자는 5년 이상의 임상 경험이 있는 전문가로 인증 받은 연구자여야 함
- 의뢰자(제약회사 또는 CRO)는 보건부에 신청서 및 근거자료를 러시아 보건부에 제출함
- 신청서 수령 후 5일 내 보건부는 신청 서류의 완결성을 확인하여 기술전문심사기관 및 윤리전문심사기관으로 서류를 전달함
- 신청서류는 전문심사기관에 의하여 심사를 받으며, 기술심사는 30근무일, 윤리심사는 15근무일이 소요됨
- 기술심사 대상 자료는 전임상 결과보고서, 임상시험 계획서 초안, 임상연구자 이력서, 타국가 수행 임상시험 결과보고서임
- 보건부는 전문심사기관의 의견을 취합해 임상시험 의뢰자에게 전달하며, 부정적인 의견이 있을 경우 해당하는 설명을 서면으로 통지함
- 임상시험의뢰자는 보건부에 임상시험승인 신청서류를 최종 제출함
- 최종 제출하는 신청 서류에는 임상시험 수행기업의 이름 및 주소, 임상시험용 의약품명/제형/용량, 임상시험 프로토콜 제목, 임상시험의 목적 및 예상 일정, 예상 임상시험대상자 등의 정보가 포함되어야 함
- 보건부 최종 승인 허가는 5근무일 내에 이루어지며, 승인 허가증이 의뢰자의 임상시험 수행을 위한 법적 근거로 사용됨
- 임상시험용의약품이 수입되는 경우 의약품 수입 면허 취득이 필요함
- 임상시험 개시, 시험 중, 종료 관련 업무는 ICH GCP 규정을 준수함
- 임상시험대상자 수 관련 규정은 따로 마련되어있지 않으므로, 제약사 또는 CRO에서 임상시험대상자 수, 수행기관의 수 및 시험 일정을 정하도록 하고 있음
러시아 임상시험계획 승인절차 모식도
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)
- 신청
- 보건부: 접수 및 신청서 전달
- 윤리위원회:전문가평가
- FSI SCMER : 과학평가
- 윤리위원회 : 결론
- FSI SCMER : 결론
- 보건부: 최종심사 및 임상시험 승인허가
- 신청자 : 최종제출
- 보건부 : 최종심사 및 결정
- 승인
의뢰자는 보건부에 신청서를 제출하고 신청서 접수 후 5일 이내 서류 확인 후 기술전문심사기관 및 윤리위원회에 신청서류를 전달합니다. 기술심사는 30일, 윤리심사는 15일이 소요되고, 각각의 심사의견이 보건부에 전달되면 보건부는 의견을 취합해 의뢰자에게 통보합니다. 의뢰자는 의견반영 및 최종 자료를 보건부에 다시 제출하고, 보건부의 최종 심사를 통해 5일 이내 임상시험 승인 허가가 결정되고 등록증명서가 발급됩니다.
출처 : 러시아 의약품 허가제도, APEC 규제조화센터, 2018
IND 제출 자료
- 아래의 관련 자료를 포함한 IND 신청서를 온라인으로 작성하여 접수하고, 출력하여 러시아 보건부에 제출함
- 임상시험의뢰자의 이름 및 주소
- 임상시험용 의약품의 제품명, 제형, 용량
- 임상시험 프로토콜
- 임상시험의 목적 및 예상 일정
- 예상 임상시험 대상자군
- 임상시험 수행 가능 의료기관 목록
- 다국적 다기관 임상시험 또는 시판 후 임상 승인을 받기 위해서는 아래와 같은 자료들이 필요함
- 임상시험승인 및 윤리성 평가 비용 지불 증명서
- 전임상 결과보고서 및 타 지역 임상시험 결과보고서
- 임상시험 프로토콜 초안
- 임상연구자 이력서 및 임상시험대상자 안내서 및 동의서 양식
- 해당제품성분 및 제제관련 정보
- 임상시험용 의약품의 제조상 특성 정보(제조업체에서 제공함)
- 임상시험용 의약품이 수입되는 경우 의약품 수입 면허 취득이 필요함
- Application letter
- 의뢰자의 법적 등록 서류(국가 등록 인증서, 세무신고서 등)
- 의약품 품질 인증서, 임상시험용 의약품 포장 라벨링 사진 또는 사본
- 수입량
- 러시아 보건부의 임상시험 승인 허가증수입면허 허가서 발급까지는 대략 1개월 소요, 수수료 무료
처리 수수료
- 의약품의 국제 다기관 임상시험이 러시아에서 일부 수행된 의약품의 품질 심사와 예상 편익/위험비 평가 수수료는 325,000 RUR 이고, 의료용 의약품의 임상 시험 수행 허가 발급 수수료는 5,000 RUR임
- 임상시험용 의약품을 수입해야 하는 경우 따라야 하는 규정
- Government Decree No. 673 of September 3, 2010 "Approval of Rules for Import and Export of Biological Materials Obtained in Clinical Trials of a medicinal product for medical use into and from the Russian Federation“
- Government Decree No. 683 of September 3, 2010 "Approval of Rules for Accreditation of Medical Institutions for the Right to Conduct Clinical Trials of Pharmaceutical Drugs for Medical Application"
- 약품 개발, 연구, 등록, 관리는 Good Clinical Practice에 의해서 규제되고, 이는 ICH GCP와 동일함
품목(시판)허가 절차
품목허가(NDA) 개요
- ‘21년도부터 EAEU 회원국의 의약품 등록 절차가 통합되어 상호인정절차(sequential procedure) 또는 분산절차(parallel procedure)를 선택할 수 있음
※ EAEU 회원국 : 러시아, 카자흐스탄, 벨라루스, 아르메니아, 키르기스스탄 (5개국)
- EAEU 통합절차를 통한 단일 품목허가 신청으로 러시아를 포함한 여러 EAEU 국가에서 동시에 품목허가를 받을 수 있음
- EAEU 통합절차 신청자는 품목허가 신청서 의 심사 및 품목허가 이후 변경사항에 대해 관리하는 Reference Member State와 그 외 통합절차를 통해 품목허가를 얻고자 하는 Other Member State를 선택할 수 있음
절차의 각 단계별 설명 및 소요기간
- 상호인정절차(순차적절차, sequential procedure)
- 절차 시작 시 신청자가 선택한 주관 국가(Reference Member State)에서 품목허가를 받은 후, 두 번째 단계에서 다른 EAEU 회원국(Other Member State)에 품목허가를 받을 수 있는 절차를 의미하며, EAEU 품목허가 신청 시 대체로 상호인정절차를 따름
- 신청자는 의약품 품목허가 신청서를 제출하기 전, 회원국의 권한 있는 기관 또는 전문가 조직에 회원국 법률에 따라 과학적 및 사전 등록 협의를 요청할 수 있음
- 품목허가 신청자는 먼저 EAEU 회원국 중 품목허가 심사를 받을 주관 국가(Reference Member State)를 선택하고, 필요 서류를 구비하여 규제당국에 제출함
- 주관 국가의 규제당국은 신청서를 제출일로부터 10영업일 이내에 서류의 행정 심사를 완료하여야 함
- 주관 국가의 심사 기관은 의약품과 시험데이터의 유효성, 안전성, 품질 등을 검토하여 평가 보고서를 작성하며, 의약품 등록 및 심사 기간은 신청일로부터 의약품 등록 허가증 발급일까지 최장 140일을 초과할 수 없음
- 주관 국가의 품목허가 승인 이후, 신청자는 관련 국가(Other Member State)에 대한 EAEU 통합 레지스터의 eCTD 및 전문가 보고서에 대한 접근 권한을 제공할 수 있음
- 신청자는 의약품 등록 및 검사 수수료 지불 증빙 및 EAEU CTD Module 1, 규범 문서(ND), 제품 특성 요약(SmPC), 라벨 및 사용 지침 등의 신청 서류를 개별 회원국의 현지 언어로 작성하여 제출함
- 관련 국가(Other Member State)에서는 신청일로부터 10영업일 이내에 의약품 등록 및 평가에 대한 수수료가 지불되지 않았거나, 규정의 요구사항을 준수하지 않았을 경우 등록 신청을 거부할 수 있음
- 다른 회원국의 권한 있는 기관(전문 조직)은 문서에 대한 액세스 권한을 얻은 후 50일영업일 동안 추가 정보를 요청할 수 있음
- 관련 국가(Other Member State)의 제출 서류 평가 결과가 긍정적일 경우, 10근무일 이내에 신청자에게 해당 국가 등록 증명서(해당 국가에서만 유효함)를 발급함
- 새로 등록된 의약품에 대한 허가증 5년간 유효하며, 유효기간이 만료되면 등록 확인(재등록)을 조건으로 의약품의 무기한 등록 증명서가 발급됨
- 분산절차 (decentralized procedure)
- 신청자가 선택한 여러 EAEU 회원국에 동시에 품목허가 신청 서류를 제출할 수 있는 절차로, 회원국의 허가 승인 절차가 병렬적으로 이루어짐
- 분산절차에서도 주관 국가(Reference Member State)를 선택하여 관할 당국의 권한이 있는 기관(전문 기관)에 품목허가 신청 서류를 제출함
- 주관 국가의 권한 있는 기관(전문 조직)은 신청서 제출일로부터 10영업일 이내에 문서에 대한 행정심사를 평가함
- 신청자는 관련 국가(Other Member State)을 선택하여 품목허가를 받고자 하는 경우, 주관 국가에 품목허가 신청 서류 제출일로부터 14영업일 내에 다른 회원국에 신청 서류 제출함
- 분산 절차 시, 주관 국가(Reference Member State)에서 의약품 품목허가 신청일로부터 의약품 등록 허가증 발급일까지 최대 140일이 소요되며, 분산 절차 통해 허가를 받고자 하는 다른 국가(the states of recognition participating in the decentralized procedure)는 최대 50 근무일이 소요됨
- 통합절차 이전에 EAEU에서 승인된 의약품에 대한 인정 절차
- 2020년 12월 31일 이전에 시장 승인을 받은 의약품은 2025년 12월 31일까지 새로운 EAEU 표준을 준수하여 통합된 형식으로 서류를 제출하여야 함
- 절차를 시작하기 전, 필요한 모든 변형(변경)에 대한 신청서를 제출하여야 하며, 통합된 형식으로 제출 시 이전에 포함되지 않은 추가(새) 데이터가 포함되어서는 안 됨
- 신청자는 등록 기준 국가를 의약품이 이미 등록된 국가로만 선택할 수 있으며, 향 후 상호승인절차를 거쳐 허가 국가를 확장할 수 있음
- 제출 서류는 「Decision of the EEC Board No. 78, EAEU 의료용 의약품의 등록 및 심사에 관한 규정(’16.03.11)」에 따라 EAEU CTD 형식으로 제출함
- 통합절차 이전에 EAEU에서 승인된 의약품에 대한 인정 절차는 최대 100일을 초과하지 않아야 함
- 해당 절차로 품목허가 승인을 받은 허가증은 5년간 유효하며, 이미 3개 이상의 회원국에서 5년 이상 등록된 의약품의 경우 유효기간이 없는 허가증이 발급됨
NDA 제출 서류
- 러시아의 의약품 등록 신청 서류 및 양식은 EAEU CTD(Common Technical Documentation) 양식을 따르며 모든 자료는 러시아어로 제출해야 하고, ‘26년부터는 전자 제출(eCTD) 의무화 됨에 따라 자료의 제출을 전자 형식으로 하는 것을 권고함
- 품목허가 등록 서류를 전자 제출(eCTD) 형식으로 제출하는 경우, 별도의 관련 서류 및 정보 제출 없이 제출할 수 있음
- 전자 제출(eCTD) 자료 요건은 「Decision of the EEC Board No. 67, 의료용 의약품의 등록 및 심사 과정에서 제출된 등록 서류의 전자 신청서(eCTD) 및 문서에 대한 요구사항의 수정 사항(’22.04.19)」 에 따름
- EAEU CTD는 5개의 모듈로 구성됨
- Module 1 : 행정정보(품목허가 신청서, IMP, 표시자제, 품질 및 제조 관련 문서, 전문가정보, 특별요구사항 등)
- Module 2 : 공통 기술 문서 요약
- Module 3 : 품질
- Module 4 : 전임상 연구 보고서
- Module 5 : 임상 시험 보고서
처리 수수료
- 의의약품의 러시아 등록 증명서 발급은 10,000 RUR 이며, 의료용 의약품의 러시아 등록 증명서 발급은 145,000 RUR 임 출처 : The Tax Code of the Russian Federation, Part 2, Section VIII, Article 333.32.1 (No. 480-FZ of December 29, 2014)
- Federal Law N 61-FZ (Federl Law on Circulation of Medicines)
- 러시아 의약품 분야의 가장 기본적인 법령으로, 의약품의 연구개발, 임상시험, 제조, 시판, 도매 및 판매업 판매, 수출입 등에 대한 주된 규제의 원칙을 제공
- Ministral Order N 1413n Guidelines for Filling Procedures and Contents of Documents necessary to assemble Master Dossiers of Medically Applied Drugs for the Purposes of the State Registration
- 의약품의 등록 서류에 관한 형식과 내용 승인에 관한 내용을 안내함
- On the Rules of marketing authorization and assessment of medicinal products for medical use
- EAEU 통합 절차에 따른 품목허가 신청을 위한 제제별 CTD 제출 요건을 명시함
EAEU 통합 절차에 따른 품목허가 신청을 위한 제제별 CTD 제출 요건을 명시, 제제구분, 규정 내 CTD 요건이 명시된 부분
제제 구분 |
규정 내 CTD 요건이 명시된 부분 |
의약품 (일반요건) |
part I of Appendix 1 |
바이오시밀러 |
Part II.10 of Appendix 1 |
생물학적제제 |
part III.12 of Appendix 1
- 혈액제제 및 혈장분획제제 : part III.12.1 of Appendix 1
- 백신 : part III.12.2 of Appendix 1
|
첨단바이오의약품 |
part IV of Appendix 1 |
신속허가 제도
- 제네릭의 경우 단축 절차 이용 가능
- 임상시험 신청 심사는 15근무일 안에 수행함
- 의약품 품질 및 편익/위험비 심사는 45근무일 안에 수행함
- 전체 심사 절차는 60근무일 안에 완료됨
- 면역생물학적제제, 인슐린, 신약의 경우 단축 절차 적용이 불가능함
- 임상시험 신청 심사는 15근무일, 품질/위험성과 유용도 비교 분석 심사를 45근무일 안에 수행하여, 전체 60근무일 안에 완료 가능 출처 : 의약품 해외시장 진출을 위한 인허가 및 시장정보, 2013, 한국보건산업진흥원
수입허가
관련법규
- 수입 관련 상위 조직 원칙은 관세동맹(Customs Union: 벨로루스, 카자흐스탄, 러시아)의 법률로 규제됨
- Federal Law N 61-FZ : 의약품 수출입의 기본 원칙
- Government Order N 673 : 임상시험용 의약품에 포함되는 생물학적 물질의 러시아연방에 수입, 수출에 대한 전체적인 규정
- Government Decree N 771 : 러시아연방에 수입되는 의료용 의약품 절차, 신청서 및 필수서류에 대한 전체적인 명령을 규정
- 의약품 수입은 별도의 허가를 취득하지 않아도 되며, 다만 제조사는 수입 의약품의 품질이 러시아의 GMP 요건에 부합하는지 확인해야 함
- 미등록 의약품에 대한 수입은 보건부(MoH)의 허가를 취득해야 함
- 미등록 의약품이란 임상시험용 의약품, 개발/연구/품질/효능/안전성 관리를 위한 샘플 의약품 등이 포함됨
러시아의 GMP 인증 절차
GMP 인증을 위한 준비사항
- (품질보증) 의약품 품질에 대한 주어진 요건을 달성하기 위한 모든 조치들을 이행해야 하는 종합적인 과제임
- 품질관리는 검체 채취, 시험(분석) 실시 및 관련 문서 작성을 포함하고, 제품 출하에 대한 허가 준비, 문서화 및 발급에 관한 지침에는 모든 필요한 시험을 진행하는 내용을 포함함
- (작업원) 회사는 자격을 갖춘 필요한 인원의 작업원을 확보해야 하고, 각 작업원의 직무는 문서로 작성하여 각 작업원이 숙지해야 함
- (시설과 설비) 시설 및 설비는 실시되는 작업에 적합하게 배치, 설계, 시공, 설치, 정비 및 유지관리 되어야 함
- 제조구역에는 생산되는 제품, 실시되는 작업 및 환경 요건에 따라 필요한 온도와 습도를 유지하고, 공기정화가 가능하도록 하는 효과적인 환기시스템이 있어야 함
- 보관구역은 다양한 종류의 재료와 제품(원자재, 포장재, 중간체, 벌크제품, 완제품, 격리 중인 제품, 출하 허가된 제품, 불합격품, 반품 또는 회수된 제품)을 적절하게 보관하기에 충분한 크기여야 함
- 일반적으로 품질관리 실험실은 제조시설과 분리되어 있어야 함
- 설비 관련, 정제수나 주사용 증류수(증류수, 탈이온수 등)용 배관은 미생물오염에 관한 행동지침과 필요한 조치가 기재되어 있는 지침서에 따라 관리해야 함
- (문서) 규격서(specification), 제조표준서(manufacturing formulae, processing and packaging instructions), 지침서/방법서(procedure) 및 기록(record)은 적절하게 작성되어야 하고, 오류가 없어야 함
- (제조) 요구되는 품질의 제품을 얻기 위해서는 제조표준서, 관련 지침서, 본 표준, 기준서 및 등록서류에 의거해 제조 작업을 실시해야 함
- (품질관리) 품질관리는 품질 요구조건에 적합하지 않은 자재 또는 제품의 사용 또는 판매를 허용하지 않기 위해서 실시됨
- 러시아 GMP 규정은 EC 가이드(EC Guide to Good Manufacturing Practice for Medicinal Products)와 일치하지만 표준을 러시아 연방 내에서 적용하고자 할 경우에는 국제 표준 대신 러시아 연방 표준을 사용할 것을 권고함
참고 문헌
- Roszdravnadzor 웹사이트
- The EFGCP Report on the Procedure for the Ethical Review of Protocols for Clinical Research Projects in Europe, 2011
- WIKIPEDIA, Economy of Russia
- WIPOLEX Tax Code of the Russian Federation (as amended in accordance with the Federal Law of the Russian Federation No. 436-FZ of 12.28.2017) (https://wipolex.wipo.int/en/text/462018)
- 세계법제정보센터(러시아의 법제정보)
- 의약품 수출활성화를 위한 허가,심사 등 지원 제도 연구, 식품의약품안전청, 2011
- 의약품 해외시장 진출을 위한 인허가 및 시장정보, 한국보건산업진흥원, 2013
- 의약품 해외시장 진출을 위한 인허가 및 시장정보, 한국보건산업진흥원, 2014
- 제2차 해외제약전문가 Insight 세미나, 한국보건산업진흥원, 2019
- 코트라(KOTRA) 국가 지역정보
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